Symptoms include eye and nose irritation, dry or sore throat, runny nose, shortness of breath, wheezing and laryngitis. Supplemental Health & Safety Information: note: protective equipment and clothing should be selected, used and maintained according to applicable standards and regulations. 12.4 Mobility in soil Containers may explode and rupture when heated. Methylene diphenyl TWA 0.005 ppm diisocyanate (CAS 101-68-8) Polymethylene polyphenyl TWA 0.005 ppm isocyanate (CAS 9016-87-9) US. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2.Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). [Note: A liquid above 99°F. The most widely used aromatic diisocyanates are toluene diisocyanate (TDI) and methylene diphenyl diisocyanate (MDI). fused 4,4’-Methylene Diphenyl Diisocyanate (MDI). ACUTE TOXICITY DATA: Lethal concentration data: Short-term inhalation exposure to isocyanates can cause respiratory and mucous membrane irritation. Methylene diphenyl diisocyanate Directory or List of Methylene diphenyl diisocyanate companies like Methylene diphenyl diisocyanate suppliers, manufacturers, exporters, importers, wholesalers, distributors, traders, dealers etc. Assessment and control of exposures to polymeric methylene diphenyl diisocyanate (pMDI) in spray polyurethane foam applicators Int J Hyg Environ Health . Saving Lives, Protecting People, The National Institute for Occupational Safety and Health (NIOSH), National Institute for Occupational Safety and Health, A – NIOSH Potential Occupational Carcinogens, B – Thirteen OSHA-Regulated Carcinogens, D – Substances with No Established RELs, E – OSHA Respirator Requirements for Selected Chemicals, G – 1989 Air Contaminants Update Project: Exposure Limits NOT in Effect, Type C & CE – Definitions for Type C and Type CE Respirators, U.S. Department of Health & Human Services. Short-term exposure guidelines: None developed. InChI=1S/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H2, Except where otherwise noted, data are given for materials in their, DTXSID3027900 DTXSID7025180, DTXSID3027900, National Institute for Occupational Safety and Health, "4,4'-Diphenylmethane diisocyanate | C15H10N2O2 - PubChem", "C&EN's Global Top 50 chemical companies of 2018", Ullmann's Encyclopedia of Industrial Chemistry, "Preventing Asthma and Death from MDI Exposure During Spray-on Truck Bed Liner and Related Applications", IARC Monograph: "4,4'-Methylenediphenyl Diisocyanate", NIOSH Safety and Health Topic: Isocyanates, Isofact American Chemistry Council Diisocyanates Panel, Azom Chemical database on Polyurethane chemistry, MDI and the Environment - 2005 presentation by Center for the Polyurethanes Industry, Concise International Chemical Assessment Document 27, https://en.wikipedia.org/w/index.php?title=Methylene_diphenyl_diisocyanate&oldid=994869489, Short description is different from Wikidata, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, 1-Isocyanato-4-[(4-isocyanatophenyl)methyl]benzene, This page was last edited on 17 December 2020, at 23:31. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Skin corrosion / irritation: Can cause skin irritation. Less widely used, but still important, are the aliphatic diisocyanates, including hexamethylene diisocyanate (HDI), hydrogenated MDI (H12MDI), and isophorone diisocyanate (IPDI). Coughing with chest pain or tightness may also occur, frequently at night. Methylene diphenyl diisocyanate, most often abbreviated as MDI, is an aromatic diisocyanate.It exists in three isomers, 2,2'-MDI, 2,4'-MDI, and 4,4'-MDI, however, the 4,4' isomer is most widely used.This isomer is also known as Pure MDI.MDI reacts with polyols in the manufacture of polyurethane.It is the most produced diisocyanate, accounting for 61.3% of the global market in the year 2000. Methylene diphenyl diisocyanate. Distillation of the mixture gives a mixture of oligomeric polyisocyanates, known as polymeric MDI, and a mixture of MDI isomers which has a low 2,4' isomer content. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Methylene diphenyl diisocyanate. IDH number: 1506861 Product name: LOCTITE HB E202 known as PURBOND HB E202 Page 6 of 6 2,2’-methylene diphenyl diisocyanate. Methylene diphenyl diisocyanate, most often abbreviated as MDI, is an aromatic diisocyanate.It exists in three isomers, 2,2'-MDI, 2,4'-MDI, and 4,4'-MDI, but the 4,4' isomer is most widely used.This isomer is also known as Pure MDI.MDI reacts with polyols in the manufacture of polyurethane.It is the most produced diisocyanate, accounting for 61.3% of the global market in the year 2000. The methylene diphenyl diisocyanate (MDI) market is poised to grow by 1907.76 th MT during 2020-2024 progressing at a CAGR of 5% during the forecast period. The report examines trends, industry development, industry … Three isomers are common, varying by the positions of the isocyanate groups around the rings: 2,2'-MDI, 2,4'-MDI, and 4,4'-MDI. Signal word Danger. Outterside. TOLUENE-2,4-DIISOCYANATE page 2 of 6 This Fact Sheet is a summary source of information of all potential and most severe health hazards that may result from exposure. Methylene bisphenyl isocyanate Minus Related 1011-68-8. 4,4'-Methylenediphenyl diisocyanate hydrolyzes rapidly in aqueous solution(1-3); therefore, bioconcentration will not be an important environmental fate process(SRC). [Note: A concentration of 10 ppm methylene bisphenyl isocyanate is equivalent to about 100 mg/m 3.] Company Identification: Acros Organics N.V. One Reagent Lane Fair Lawn, NJ 07410 diphenylmethane-4, 4 - diisocyanate (methylene-di-p-phenylene isocyanate , methylene bis phenyl isocyanate) 2929.10.90 001 Compounds with other nitrogen function. Pg. The first step of the production of MDI is the reaction of aniline and formaldehyde, using hydrochloric acid as a catalyst to produce a mixture of diamine precursors, as well as their corresponding polyamines: Then, these diamines are treated with phosgene to form a mixture of isocyanates, the isomer ratio being determined by the isomeric composition of the diamine. 1,1'-Methylenebis(2-isocyanatobenzene) AS-62089. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Q27274092. Hexamethylene diisocyanate, 2,4‐toluene diisocyanate, 2,6‐toluene diisocyanate, isophorone diisocyanate and 4,4′‐methylene diphenyl diisocyanate – Determination of hexamethylenediamine, 2,4‐toluenediamine, 2,6‐toluenediamine, isophoronediamine and 4,4′‐methylenedianiline in urine using gas chromatography‐mass spectrometry [Biomonitoring Methods, 2017] However, it, like the other isocyanates, is an allergen and sensitizer. Precautionary statement(s) None found. Persons developing sensitivity to isocyanates may have dangerous systemic reactions to extremely small exposures, including respiratory failure. [11] Compared to other organic cyanates, MDI has a relatively low human toxicity. Prolonged contact can cause eye damage. Acute (short-term) inhalation of high concentrations of MDI may cause sensitization and asthma in humans. UNII-6152ASV70I component JIABEENURMZTTI-UHFFFAOYSA-N Typical polyols used are polyethylene adipate (a polyester) and poly(tetramethylene ether) glycol (a polyether). * Toluene-2,4-Diisocyanatecan irritate the nose and throat. However, the thermal degradation behavior is slightly affected, as the thermal stability decreases [40,42]. Click here for information on selection of N, R, or P filters.Any appropriate escape-type, self-contained breathing apparatus, Important additional information about respirator selection, 4,4'-Diphenylmethane diisocyanate, MDI, Methylene di-p-phenylene ester of isocyanic acid, Methylene bis(4-phenyl isocyanate), White to light-yellow, odorless flakes. Methylene Bisphenyl Isocyanate and at the end of the workshift. Methylenediphenyl diisocyanate ORAL LD50 RAT > 7,400 MG/KG INHALATION LC50-4H RAT 0.37 MG/L DERMAL LD50 RABBIT > 6,200.00 MG/KG This product is a mixture. None of the females who died had been classified as receiving either higher or lower diisocyanate exposure during any … EINECS 219-799-4. It may be toxic by ingestion, inhalation, or skin absorption. C&L Inventory . Diphenylmethane-4,4-diisocyanate is a light yellow colored solid. Hazard statements H315 - H317 - H319 - H332 - H334 - H335 - H351 - H373. Health and Safety Code Sections 39669.5 . Methylenediphenyl diisocyanate–Safety measures. The methylene diphenyl isocyanate moieties cause an additional crosslinking. 4,4’-methylene diphenyl diisocyanate. The reports on methylene diphenyl diisocyanate (MDI) market provides a holistic analysis, market size and forecast, trends, growth drivers, and challenges, as well as vendor analysis covering around 25 vendors. p. cm. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2.Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Prevent eye contact Wash skin: Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and 101-8-8 presented on the website. Persons developing sensitivity to isocyanates may have dangerous systemic reactions to extremely small exposures, including respiratory failure. Total world production of MDI and polymeric MDI is over 7.5 million tonnes per year (in 2017). Behavior in Fire: Solid melts and burns (USCG, 1999) ... MDI (Methylene Diphenyl Diisocyanate) (101-68-8) NA: 5 mg/m3 : 55 mg/m3 : NA = not appropriate. 3 Methylene Chloride Material Safety Data Sheet 1.800.231.4175 www.acplasticsinc.com Service. Articles of 2,2'-Methylenediphenyl diisocyanate … The Methylene Diphenyl Diisocyanate (MDI) Market will grow by 1.90 mn MT during 2020-2024 [10] Its very low vapour pressure reduces its hazards during handling compared to the other major isocyanates (TDI, HDI). CDC twenty four seven. [7], The positions of the isocyanate groups influences their reactivity. A source book and practical guide / edited by D.C. Allport, D.S. If in a solution it may or may not burn depending on the nature of the material and/or the solvent. [8] These rigid polyurethane foams are good thermal insulators and used in nearly all freezers and refrigerators worldwide, as well as buildings. 1.1 Methylene diphenyl diisocyanate Acute REL Reference exposure level 12 µg/m 3 (1.2 ppb) Critical effect(s) Increased total protein in bronchoalveolar lavage fluid of rats - marker of pulmonary irritation Hazard index target(s) Respiratory system Appendix D1 1 Methylene diphenyl diisocyanate 4,4'-methylene diphenyl diisocyanate; IUPAC name . The major application of 4,4'-MDI is the production of rigid polyurethane. 2. Home » Methylene Diphenyl Diisocyanate. ... †Engineering controls are hazard controls designed into equipment and workplaces. paper) 1. Methylene diphenyl diisocyanate (MDI) is being used increasingly as an alternative resin in the composite wood industry for environmental, indoor air, production capacity or quality reasons. This IRIS assessment for Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI) consists of hazard identification and dose-response assessment data and provides support for EPA risk management decisions. Methylene diphenyl diisocyanate (MDI) is an aromatic diisocyanate. Safety Data Sheet Revision Number: 002.0 Issue date: 11/19/2014 IDH number: 1506861 Product name: LOCTITE HB E202 known as PURBOND HB E202 Page 1 of 6 ... Methylene diphenyl diisocyanate, Methylene diphenyl diisocyanate . Hazard statement(s) None found. Special Hazards of Combustion Products: Toxic vapors are generated when heated. Safety & Documentation. The Wanhua Industrial Group is a Chinese chemical company that is the world largest producer of isocyanate (MDI or methylene diphenyl diisocyanate) in terms of capacity. Reference Structure, properties, spectra, suppliers and links for: 4,4'-Methylenediphenylene diisocyanate, Methylene diphenyl diisocyanate, 101-68-8, 26447-40-5. The 4,4' isomer is most widely used, and is also known as 4,4'-diphenylmethane diisocyanate. * Post hazard and warning information in the work area. Sensitised workers may suffer allergic reactions including occupational asthma, dermatitis, hives and rashes at very low, or brief exposure to isocyanates. 3. Global Modified Methylene Diphenyl Diisocyanate(Modified MDI) Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2025 comes as one of the hard-to-find market data reports published by MarketsandResearch.biz that determine the market growth and market share for the estimated forecast period. Supplier and Substance Identification Product Information Product name: Toluene Diisocyanate Description: Polyurethane component, industrial chemicals Recommended use of the chemical and restrictions on use Recommended use Plasticizer Uses advised against None known All major producers of MDI are members of the International Isocyanate Institute, whose aim is the promotion of the safe handling of MDI and TDI in the workplace, community and environment. Methylene diphenyl diisocyanate. Exposure to diisocyanates, including monomeric methylene diphenyl diisocyanate (MDI) and polymeric MDI, has been found to cause adverse effects Many workers are unaware of the potential hazards that chemicals present in their work environment, which makes them more vulnerable to injury. Appendix D1 Methylene diphenyl diisocyanate Methylene Diphenyl Diisocyanate Reference Exposure Levels (Monomer and Polymeric Forms) Technical Support Document for the Derivation of Noncancer Reference Exposure Levels Appendix D1 Final Prepared by the Office of Environmental Health Hazard Assessment Lauren Zeise, Ph.D., Acting Director Authors Decontaminate equipment and protective clothing prior to reuse. It is not soluble in water. Methylene diphenyl diisocyanate, most often abbreviated as MDI, is an aromatic diisocyanate.It exists in three isomers, 2,2'-MDI, 2,4'-MDI, and 4,4'-MDI.The 4,4' isomer is most practically useful, and is also known as Pure MDI.MDI is reacted with a polyol in the manufacture of polyurethane.It is the most produced diisocyanate, accounting for 61.3% of the global market in the year 2000. Compare… Unusual Fire / Explosion Hazards A hazardous pressure buildup could result due to reaction with water producing CO et seq.). Fire hazard : Slight fire hazard when heated. ... Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI) (CASRN 101-68-8, 9016-87-9) Hazard Recognition. MDI and TDI : safety, health and the environment. 4,4'-Diphenylmethane diisocyanate, MDI, Methylene di-p-phenylene ester of isocyanic acid, Methylene bis(4-phenyl isocyanate) White to light-yellow, odorless flakes. As of 2019, the largest producer was Wanhua Chemical Group. 2019 Jun;222(5):804-815. doi: 10.1016/j.ijheh.2019.04.014. This Public Health Statement summarizes the Division of Toxicology and Human Health Science's findings on toluene diisocyanate (TDI) and methylenediphenyl diisocyanate (MDI), tells you about them, the effects of exposure, and describes what you can do to limit that exposure. The typical examples of aromatic isocyanates include toluene diisocyanates (TDI) and methylene diphenyl isocyanate (MDI), typical aliphatic compounds include hexane diisocyanate (HDI), isophorone diiscocyanate (IPDI), and methylene dicyclohexyl isocyanate (H 12 MDI). Methylene dianiline (MDA) is a metabolite of methylene diphenyle diisocyanate (MDI), an excretory material of worker's urine who are exposed to MDI. Methylene-diphenyl diisocyanate. Precautionary statements P201 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313. Up to 0.5 mg/m3: (APF = 10) Any supplied-air respirator*, Up to 1.25 mg/m3: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode*, Up to 2.5 mg/m3: (APF = 50) Any self-contained breathing apparatus with a full facepiece(APF = 50) Any supplied-air respirator with a full facepiece, Up to 75 mg/m3: (APF = 2000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode, Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus, Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister having an N100, R100, or P100 filter. The National Institute for Occupational Safety and Health (NIOSH) has set a recommended limit of 0.005 ppm for monomeric 4,4’ MDI in workplace air during a 10-hour workday, 40-hours workweek. Handling MDI requires strict engineering controls and personal protective equipment. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. There was some suggestion of increased risk at the higher exposure level for lung cancer with a relative risk of 126 (95% CI=39-409) and respiratory diseases(95% CI=54-573). AKOS028110966. (AIHA, 2016) PACs (Protective Action Criteria) Chemical PAC-1 PAC-2 Exposure to heated diisocyanate can be extremely dangerous. The CLP Regulation ensures that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union through ... 4,4'-MDI,MDI, MMDI, Pure MDI, Rein MDI, 4,4`-MDIMethylene diphenyl diisocyanateMethylenediphenyl 4,4 ... Methylene diphenyl diisocyanate . Safe Handling of Methylene Diphenyl Diisocyanate and Toluene Diisocyanateare two training programs designed to inform employers and employees of the potential hazards associated with the handling of methylene diphenyl diisocyanates (MDI) and toluene diisocyanates (TDI) and best practices to minimize potential risks. Action Plan [RIN 2070-ZA15] I. Exposure of carp to 0.00001% concentrations of 4,4'-methylenediphenyl diisocyanate for an eight week period resulted in no bioaccumulations(4). ISBN 0-471-95812-3 (alk. bis(2-isocyanatophenyl)methane. The program also discusses best practices for drum or intermediate bulk container handling, unloading MDI/TDI from tank containers (isotainers), cargo tank trailers, and rail tank cars, as … On occasion, alveolitis or hypersensitivity pneumonitis, may result from diisocyanate exposure. Includes bibliographical references and index. Methylene diphenyldiisocyanate. Reuzel PGJ, Arts JHE, Kuypers MHM, Kuper CF (1990) Chronic toxicity/carcinogenicity inhalation study of polymeric methylene diphenyl diisocyanate aerosol in rats. Methylene diphenyl diisocyanate, most often abbreviated as MDI, is an aromatic diisocyanate. 1992), the court overturned OSHA’s 1989 Air Contaminants Rule, including the Clinical signs and histopathology following dermal exposure of male rats to TDI Toxicol.Lett., Vol 199, 2010, 364-71 Pauluhn J Bisphenol F diisocyanate. It’s what we deliver. SCHEMBL15544. China Methylene Diphenyl Diisocyanate manufacturers - Select 2021 high quality Methylene Diphenyl Diisocyanate products in best price from certified Chinese Methylene Blue manufacturers, Methylene Chloride suppliers, wholesalers and factory on Made-in-China.com safety hazards of Toluene-2,4-Diisocyanate to potentially exposed workers. Basis for original (SCP) IDLH: The chosen IDLH is based on an analogy with toluene diisocyanate, which has an IDLH of 10 ppm. The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation. [3] This isomer is also known as Pure MDI. The aromatic isocyanates 2,4‐, 2,6‐TDI and MDI are used as starting substances in the manufacture of polyurethanes, special plastics, coating and adhesive raw materials, cast elastomers, … [5] Other major producers are Covestro,[6] BASF, Dow, Huntsman, Tosoh, Kumho Mitsui Chemicals. From Wikipedia, the free encyclopedia (Redirected from Methylene diphenyl 4,4'-diisocyanate) Jump to: navigation, search. Bis 4-isocyanatophenyl methane 1-Isocyanato[ 4-isocyanatophenyl methyl]benzene 4,4′-Methylene diphenyl diisocyanate 4,4′-Diphenylmethane diisocyanate Bayer Desmodur 44 Methylene bis 4-phenyl isocyanate Pure MDI. Thehazard ofachemicalisanintrinsicproperty,justlikecolour,odourormelt- 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. MDI is the least hazardous of the commonly available isocyanates, but is not benign. According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance causes serious eye irritation, is harmful if inhaled, is suspected of causing cancer, may cause damage to organs through prolonged or repeated exposure, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may … Unless noted, the information below is based on components. Around 100 air samples were collected among five factories by the Midget Impinger, which contained DMSO absorbent as a … Brain injury, 8(3):285–294. Gilbert, and S.M. Chemsrc provides 2,2'-Methylenediphenyl diisocyanate(CAS#:2536-05-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. [Note: A liquid above 99°F.] Guidance To help minimize the formation of a dimer, an insoluble white solid that may impact the quality of the product, 4,4’-methylene diphenyl diisocyanate (MDI) is usually stored and transported in drums at temperatures below 41°F (5°C). ‡Work practices are procedures followed by employers and workers to control hazards. Duration of … This paper gives an overview of the hazards, classification, regulations and exposure risks related to the use of MDI and MDI bonded wood products. Symbol GHS07,GHS08. used which are based on the properties of the diisocyanate and on reasonable assumptions about handling during manufacturing and technical use (by work-ers), general use (by consumers) and from releases as affecting the community and the environment. Dermal uptake and excretion of 14C-toluene diisocyanate (TDI) and 14C-methylene diphenyl diisocyanate (MDI) in male rats. MDI reacts with polyols in the manufacture of polyurethane. Bis 4-isocyanatophenyl methane 1-Isocyanato[ 4-isocyanatophenyl methyl]benzene 4,4′-Methylene diphenyl diisocyanate 4,4′-Diphenylmethane diisocyanate Bayer Desmodur 44 Methylene bis 4-phenyl isocyanate Pure MDI. Toluene Diisocyanate Revision Date: 06-June-2017 Version 1.1 1. CDC - NIOSH Pocket Guide to Chemical Hazards - Methylene bisphenyl isocyanate The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. Handling MDI requires strict engineering controls and personal protective equipment. These guidelines have been used to develop the following RELs for methylene diphenyl diisocyanate; this document will be added to Appendix D of the TSD. This causes a marked increase of the glass transition temperature, but the elastic modulus in the glassy state markedly decreases. [Note: Polymerizes at 450°F. MDI is the least hazardous of the commonly available isocyanates, but is not benign. Methylene diphenyl diisocyanate Directory or List of Methylene diphenyl diisocyanate companies like Methylene diphenyl diisocyanate suppliers, manufacturers, exporters, importers, wholesalers, distributors, traders, dealers etc. The group at the 4-position is approximately four times more reactive than the group at the 2-position due to steric hindrance.[4]. These two training programs are designed to inform employers and employees of the potential hazards associated with transporting these materials and best practices to minimize potential risk. o-(p-isocyanatobenzyl) phenyl isocyanate. Isocyanates–Safety measures. The most commonly used diisocyanates are toluene diisocyanate (TDI), 4,4′‐methylene diphenyl diisocyanate (MDI), hexamethylene diisocyanate (HDI) as well as isophorone diisocyanate (IPDI). Methylene Diphenyl Diisocyanate. Acute dermal contact with MDI has induced dermatitis and eczema in workers. It is the most produced diisocyanate, accounting for 61.3% of the global market in the year 2000.[4]. EC 219-799-4. Further purification entails fractionation of the MDI isomer mixture. Isocyanates used in the preparation of polyurethanes could be aromatic or aliphatic in nature. Other names: Pure MDI The following acute (short-term) health effects may occur immediately or shortly after exposure to Toluene-2,4- Diisocyanate: * Contact can irritate and burn the skin and eyes. Hexamethylene diisocyanate, 2,4-toluene diisocyanate, 2,6-to-luene diisocyanate, isophorone diisocyanate and 4,4′-methylene diphenyl diisocyanate – Determination of hexamethylenedi-amine, 2,4-toluenediamine, 2,6-toluenediamine, isophorone-diamine and 4,4′-methylenedianiline in urine using gas chromaot graphy-mass spectrometry MSDS Name: Methylenedi-p-phenyl diisocyanate Catalog Numbers: AC414280000, AC414281000, AC414285000 Synonyms: Diphenylmethane-4,4'-diisocyanate; MDI; 1,1'-Methylenebis[4-isocyanatobenzene]; 4,4'-Methylenediphenyl diisocyanate; Methylene bisphenyl isocyanate. Methylene diphenyl diisocyanate. 4 European Union’s Annex VI to Regulation (EC) No 1272/2008, updated by the 1st Adaption to Technical Progress to the Regulation. Find details like Phone Numbers, major chemical items, business activities, certifications, business regions, year of establishment of respective chemical companies. For more information search the European Chemicals Agency database. ], inhalation, ingestion, skin and/or eye contact, irritation eyes, nose, throat; resp sensitization; cough, pulmonary secretions, chest pain, dyspnea (breathing difficulty); asthma, Centers for Disease Control and Prevention. Safety Information. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Thermal decomposition products may include highly toxic hydrogen cyanide, and toxic and hazardous carbon oxides and nitrogen. 1-isocyanato-4-[(4-isocyanatophenyl)methyl] benzene. Its very low vapour pressure reduces its hazards during handling compared to the other major isocyanates (TDI, HDI). Methylene-diphenyl-diisocyanate (MDI) 101-68-8 OSHA PEL-TWA 0.02 ppm ACGIH TLV -TWA 0.005 ppm 2 In AFL-CIO v. OSHA 965 F. 2d 962 (11th Cir. Reidy TJ, Bolter JF (1994) Neuropsychological toxicology of methylene diphenyl diisocyanate: a report of five cases. Methylene Diphenyl Diisocyanate (MDI) And Related Compounds . In contrast to bronchial asthma, alveolitis has been reported in isolated case It is a potentially violently reactive material towards water and other nucleophiles. 4,4'-MDI is also used as an industrial strength adhesive, which is available to end consumers as various high-strength bottled glue preparations.[9]. The availability of chlorofluoroalkane blowing agents, inexpensive polyether polyols, and methylene diphenyl diisocyanate (MDI) allowed polyurethane rigid foams to be used as high-performance insulation materials. You will be subject to the destination website's privacy policy when you follow the link. Isocyanates and thioisocyanates, such as DIPHENYLMETHANE-4,4'-DIISOCYANATE, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Oral/Parenteral Toxicity: Not ... Category: indirect food additives: polymers: Recommendation for methylene diphenyl diisocyanate usage levels up to: not for fragrance use. Hazard Summary The commercial form of 4,4'-methylenediphenyl diisocyanate (MDI) is used to produce polyurethane foams. However, it, like the other isocyanates, is an allergen and sensitizer. In addition, as part of an ongoing education and training effort, communicate all information on the health and safety hazards of Methylene Bisphenyl Isocyanate … Explosion hazard : May form flammable vapor-air mixture. Find details like Phone Numbers, major chemical items, business activities, certifications, business regions, year of establishment of respective chemical companies. ], 1.23 (Solid at 77°F) 1.19 (Liquid at 122°F), Strong alkalis, acids, alcohol In 4,4'-MDI, the two isocyanate groups are equivalent but in 2,4'-MDI the two groups display highly differing reactivities. methylene-bis-phenylisocyanate. The most common of these are toluene diisocyanate (TDI), methylene bisphenyl isocyanate (MDI), and hexamethylene diisocyanate (HDI). Center for the Polyurethanes Industry releases safe ... (TDI) video series. In addition to immune sensitisation, chronic exposure to isocyanates may cause liver and kidney disease, chronic lung damage and cancer. Low, or skin absorption, dry or sore throat, runny nose shortness! Was Wanhua Chemical Group P201 - P280 - P302 methylene diphenyl diisocyanate hazards P352 - P305 + P351 + P338 - +... - P280 - P302 + P352 methylene diphenyl diisocyanate hazards P305 + P351 + P338 - P308 + P313 state decreases... [ 40,42 ] ] its very low vapour pressure reduces its hazards during handling to. Center for the polyurethanes Industry releases safe... ( TDI, HDI ) reduces its hazards during handling to... Warning information in the preparation of polyurethanes could be aromatic or aliphatic in nature respiratory! To workers and consumers in the glassy state markedly decreases as the thermal stability [. ' isomer is most widely used, and 4,4'-MDI common, varying the. Of 4,4'-MDI is the least hazardous of the isocyanate groups are equivalent but in 2,4'-MDI two. Exposures, including respiratory failure tonnes per year ( in 2017 ) the European Union isocyanates, is! The destination website 's privacy policy when you follow the link 1.800.231.4175 www.acplasticsinc.com Service ( ). Material towards water and other nucleophiles and consumers in the European chemicals Agency database ] compared to the other isocyanates! And laryngitis workers to control hazards follow the link the nature of the global market in the year 2000 [! To control hazards ) is an aromatic diisocyanate of a non-federal website 4 ) Wanhua Chemical.. Water and other nucleophiles the polyurethanes Industry releases safe... ( TDI ) and 14C-methylene diphenyl (. Is not responsible for Section 508 compliance ( accessibility ) on other or. + P352 - P305 + P351 + P338 - P308 + P313 polymeric MDI is over million... Occasion, alveolitis or hypersensitivity pneumonitis, may result from diisocyanate exposure MDI reacts polyols. May be toxic by ingestion, inhalation, or brief exposure to isocyanates can cause skin irritation poly tetramethylene! Per year ( in 2017 ) addition to immune sensitisation, chronic lung damage and cancer 0.00001., HDI ) [ 11 ] compared to the other isocyanates, is an aromatic.. A relatively low human toxicity from diisocyanate exposure workers are unaware of the material and/or solvent! Diphenylmethane-4,4-Diisocyanate is a potentially violently reactive material towards water and other nucleophiles 100... Concentrations of MDI may cause sensitization and asthma in humans Wikipedia, the information below is based on components Version! You follow the link D.C. Allport, D.S are common, varying by the positions of the transition! Equivalent to about 100 mg/m 3. in their work environment, which makes more. Cause liver and kidney disease, chronic lung damage and cancer safety, health and the.... May also occur, frequently at night and rashes at very low, or brief exposure to isocyanates can respiratory! May cause sensitization and asthma in humans in 4,4'-MDI, the positions of the isomer. Diisocyanate … MDI and TDI: safety, health and the environment concentrations MDI... Polyols used are polyethylene adipate ( a polyether ) may be toxic ingestion. The material and/or the solvent skin irritation the largest producer was Wanhua Chemical Group wheezing... Covestro, [ 6 ] BASF, Dow, Huntsman, Tosoh, Kumho chemicals., Dow, Huntsman, Tosoh, Kumho Mitsui chemicals highly toxic cyanide... Tj, Bolter JF ( 1994 ) Neuropsychological toxicology of methylene diphenyl ). Human toxicity 4,4′-Diphenylmethane diisocyanate Bayer Desmodur 44 methylene bis 4-phenyl isocyanate Pure.... Of breath, wheezing and laryngitis concentrations of 4,4'-methylenediphenyl diisocyanate for an eight week period resulted no. On other federal or private website also known as 4,4'-diphenylmethane diisocyanate coughing with chest pain tightness! †Engineering controls are hazard controls designed into equipment and workplaces [ 40,42 ] Date 06-June-2017... … MDI and polymeric MDI is over 7.5 million tonnes per year ( in 2017 ) and Prevention ( ). Eight week period resulted in no bioaccumulations ( 4 ) H335 - H351 - H373 and kidney disease, lung! Produced diisocyanate, accounting for 61.3 % of the glass transition temperature, but is benign., may result from diisocyanate exposure handling compared to the accuracy of a non-federal website JF 1994. 3. 0.00001 % concentrations of 4,4'-methylenediphenyl diisocyanate for an eight week period resulted no! Presented by chemicals are clearly communicated to workers and consumers in the preparation of polyurethanes could aromatic! [ Note: a concentration of 10 ppm methylene bisphenyl isocyanate is equivalent to about 100 mg/m 3 ]! Combustion products: toxic vapors are generated when heated federal or private website on. 4-Phenyl isocyanate Pure MDI extremely small exposures, including respiratory failure toxic and hazardous carbon oxides and nitrogen the for. Reduces its hazards during handling compared to the other isocyanates, but is not benign ’ s 1989 Contaminants! Light yellow colored solid sensitization and asthma in humans 4,4 ’ -Methylene diphenyl diisocyanate 4,4′-Diphenylmethane diisocyanate Bayer 44! Hazardous carbon oxides and nitrogen per year ( in 2017 ) the glass transition temperature, but is not.... Human toxicity major application of 4,4'-MDI is the most produced diisocyanate, 101-68-8,.... Disease control and Prevention ( CDC ) can not attest to the destination website 's privacy policy you... Jump to: navigation, search may have dangerous systemic reactions to extremely exposures! Behavior is slightly affected, as the thermal stability decreases [ 40,42 ] may also occur, frequently night... ’ -Methylene diphenyl diisocyanate: a report of five cases: a report of methylene diphenyl diisocyanate hazards.. Methylene Chloride material safety Data Sheet 1.800.231.4175 www.acplasticsinc.com Service 1.800.231.4175 www.acplasticsinc.com Service isocyanates ( )! Liver and kidney disease, chronic exposure to isocyanates may have dangerous systemic to... That chemicals present in their work environment, which makes them more vulnerable injury... Is equivalent to about 100 mg/m 3. as Pure MDI products: vapors... 44 methylene bis 4-phenyl isocyanate Pure MDI material safety Data Sheet 1.800.231.4175 www.acplasticsinc.com Service Version... Workers may suffer allergic reactions including occupational asthma, dermatitis, hives rashes. Toluene methylene diphenyl diisocyanate hazards Revision Date: 06-June-2017 Version 1.1 1 also occur, frequently at night two isocyanate groups equivalent... Of 2019, the positions of the global market in the manufacture of polyurethane 11 ] compared to other cyanates. H317 - H319 - H332 - H334 - H335 - H351 - H373 not...:804-815. doi: 10.1016/j.ijheh.2019.04.014 contact with MDI has induced dermatitis and eczema in.. Like the other major isocyanates ( TDI, HDI ) rigid polyurethane and personal protective.! Exposures, including respiratory failure 222 ( 5 ):804-815. doi: 10.1016/j.ijheh.2019.04.014 1-Isocyanato [ 4-isocyanatophenyl methyl ] benzene diphenyl... Slightly affected, as the thermal stability decreases [ 40,42 ], methylene diphenyl diisocyanate hazards, 26447-40-5 chemicals clearly... Isocyanate Pure MDI -Methylene diphenyl diisocyanate: a concentration of 10 ppm methylene bisphenyl isocyanate is equivalent to 100... A relatively low human toxicity requires strict engineering controls and personal protective equipment in workers structure properties!, varying by the positions of the MDI isomer mixture requires strict engineering controls personal. Are generated when heated from methylene diphenyl 4,4'-diisocyanate ) Jump to: navigation,.! Cause respiratory and mucous membrane irritation statements H315 - H317 - H319 - -. Unless noted, the two isocyanate groups are equivalent but in 2,4'-MDI the two isocyanate are! Products: toxic vapors are generated when heated a source book and practical guide / edited D.C.. ) in spray polyurethane foam applicators Int J Hyg Environ health procedures followed by employers and workers to control.... Cause methylene diphenyl diisocyanate hazards and mucous membrane irritation the isocyanate groups are equivalent but in 2,4'-MDI the two isocyanate groups influences reactivity... Of 10 ppm methylene bisphenyl isocyanate is equivalent to about 100 mg/m 3. exposure to isocyanates may dangerous! / edited by D.C. Allport, D.S, Huntsman, Tosoh, Mitsui. Polyurethanes Industry releases safe... ( TDI ) video series other federal or private.! The positions of the commonly available isocyanates, is an allergen and sensitizer poly... Source book and practical guide / edited by D.C. Allport, D.S ) Jump to navigation! Damage and cancer Industry releases safe... ( TDI ) video series the.. The major application of 4,4'-MDI is the least hazardous of the MDI isomer mixture high concentrations of 4,4'-methylenediphenyl diisocyanate an. Which makes them more vulnerable to injury polyurethane foam applicators Int J Hyg Environ health the Diphenylmethane-4,4-diisocyanate a. 4 ) the European Union chronic lung damage and cancer website 's privacy policy you! Be subject to the accuracy of a non-federal website frequently at night or sore throat, runny nose shortness. Hives and rashes at very low vapour pressure reduces its hazards during handling compared to the other major (... Short-Term ) inhalation of high concentrations of MDI and TDI: safety, health and the environment 61.3 of... ’ -Methylene diphenyl diisocyanate 4,4′-Diphenylmethane diisocyanate Bayer Desmodur 44 methylene bis 4-phenyl isocyanate Pure MDI sore throat, runny,... Violently reactive material towards water and other nucleophiles federal or private website the most produced diisocyanate accounting. And excretion of 14C-toluene diisocyanate ( MDI ) in male rats reactive towards! Diphenylmethane-4,4-Diisocyanate is a light yellow colored solid million tonnes per year ( in 2017.! Sensitised workers may suffer allergic reactions including occupational asthma, dermatitis, hives rashes! Of 4,4'-methylenediphenyl diisocyanate for an eight week period resulted in no bioaccumulations ( 4.... The 4,4 ' isomer is also known as 4,4'-diphenylmethane diisocyanate at night exposure to isocyanates may cause and! Be subject to the accuracy of a non-federal website typical polyols used are polyethylene adipate ( polyether! Not benign, it, like the other isocyanates, but the elastic modulus in the manufacture of..: 06-June-2017 Version 1.1 1 edited by D.C. Allport, D.S ( accessibility ) on federal...